please answer the following questions for a Biochemistry class thoroughly and correctly. answer each of the Questions separately and make sure to use references to site every piece of information used as this assignment will be checked by turnitin.com
1) How are single-stranded regions of DNA, unwound by helicases, maintained?
2) Describe the process of DNA replication in bacteria and eukaryotes including the roles of DNA polymerases, helicases, single strand binding proteins, topoisomerases, and the role of the primase for synthesizing RNA primers and Okazaki fragments for lagging strand DNA synthesis.
3) Name the types of DNA repair, categorized in groups.
4) Describe the Ames test.
5) Why is thymine used in DNA instead of uraci
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for the following two questions you may site sources if needed but not required.
1) Create a hypothesis that would explain the mechanism for Influenza virus antigenic drift. Please be detailed and explain why antigenic drift results in amino acid changes rather than reassortment of the viral genome.
2) The rapid evolution of type A influenza virus by antigenic shift has serious implications for the human population. For example, the type A Influenza virus strain H5N1, sometimes found in domestic poultry, rarely infects humans but when infected, Avian H5N1 kills about 60% of the infected humans.
Create a hypothesis that would mechanistically explain antigenic shift and how antigenic shift could possibly create a hybrid H5N1 Influenza virus that would be highly infectious, and highly lethal, for humans.
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