this the sources are peer review i want it not a perfect and i want it very semple.1- Tsukasa et al (2015), Pancreatic cancer immunotherapy using a tumor lysate vaccine, engineered to express [alpha]-gal epitopes, targets pancreatic cancer stem cells.
2- Jiang et al (2014), Knockdown of glucose-regulated protein 78 enhances poly(ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress.
3- Humphris et al (2014), Clinical and pathologic features of familial pancreatic cancer.
4- Jonathan et al (2014), Pancreatic stellate cells and pancreas cancer: Current perspectives and future strategies.
5- AG Moir et al (2014), Arrested development and the great escape – The role of cellular senescence in pancreatic cancer.
————————————————————————————— Jiang et al , Knockdown of glucose-regulated protein 78 enhances poly (ADP-ribose) polymerase cleavage in human pancreatic cancer cells exposed to endoplasmic reticulum stress,(2014) , Chiba university , Japan.
The most dangerous tumor of all cancers is the pancreatic cancer. There is no efficient cure found or medicine, except surgery to remove the infected organ from the body. Unfortunately there are no warning signs for this disease so we can prevent the development of the cancer.
Dr.Jiang et al says they need more studies about the pancreatic cancer to know how to deal with him. In this study and after the experiments we did on the tumor we found there is a relation between the stress and tumor growth and developing. The stress makes the cells destroy themselves. We found that the articulation of the stress is connected with increasing the cancer cells. The test show that the protein (GRP78) is interfering to support the split in the body cells for the pancreatic cancer.
They did a lot of test on the cancer cells in the human body, and we found the cancer cells will grow if we put it in sigma plus to it fetal bovine serum ten percentages concentrate under 37o C and that is the body temperature. The conclusion of this study we did it on the protein levels (GRP78) we toke from four cells line in the pancreatic cancer shows. The number of the (GRP78) in the cells of the pancreatic cancer can support and account to change the sensitivity to the chemotherapy in the pancreatic cancer.
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