Get the protein sequence from NCBI or other data base.
Blast (using blastP) the data base and retrieve 5 sequences from other organisms and align them in the BioEdit program**. (You should already have Bioedit working). Highlight conserved amino acids.
In your structure find the conserved amino acids and identify where they are (highlight them on the structure. Pick 5 areas of identity and if possible describe their function. Determine if other structures of the same protein exists with substrates or inhibitors bound. Locate the small molecule binding site in the protein and report which amino acids in the aligned sequences that interact with the small molecule(substrate, inhibitor or modulator).
You should have at least three primary research articles that you reference more may be helpful. Write a five page description of your project. Support your data with graphs pictures and alignments (not included in the page limit).
Last Completed Projects
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