Signal Transduction Project Guidelines1. Your report, both oral and written parts, is designed to be a literature review as well as a chance to design an experiment. You will select a signal transduction pathway to research (glycogen synthase kinase 3). For this topic, I would like you to find current information (most of your references should be less than five years old) describing a signal transduction pathway or a portion of a pathway (and related disorders if appropriate). Your task is to collect the research, analyze it, and put it into a coherent narrative. In addition, to the literature review, you are to design and describe an experiment that you would conduct that would assist in elucidating additional functions or connections in the pathway. You should provide your hypothesis, the experimental steps, and indicate the results that would support your hypothesis as well as the results that would not support your hypothesis.2. For your signal transduction pathway, I want you to find out as much structural and chemical information as possible. Using sites such as NCBI and Swiss-Prot, you should find a wealth of information. In addition, find out what other pathways that have similar structures and functions to your pathway of choice.3. Different types of reference sources are permissible. However, the bulk of the reference material cited should be from peer-reviewed publications. Peer-reviewed journals are those whose published articles were reviewed and approved by scientists in the field prior to publication. These scientists (or peers) review the published article for the quality of the science and accuracy of the described scientific work. In a sense, these scientists grade both the written article and the science described by the article. Only articles that are approved appear in print. If you are unsure whether a journal publishes only peer-reviewed articles, then ask.4. It is ok to have information from other sources such as the web or nonpeer-reviewed journals, but they should not be the primary sources of information. The information in these sources has likely not been effectively evaluated for scientific accuracy or quality. Although magazines such as Time and newspaper articles are sometimes great places for ideas, the science described by these publications may not always be accurate or reviewed by other qualified scientists in the discipline.5. There is no required length for the written report. Although I would be surprised if you can effectively review the material in less than twelve pages. In general, the papers are likely to be between 12 and 15 pages. A reference page should be included that lists cited work. I will describe how to cite referenced material in class.
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